Introduction: Late life depression is one of the most frequent disorders in elderly and often remains unrecognized. One of the reasons why late life depression often passes unrecognized is comorbidity – a number of different chronic diseases coexist with depression. rnObjective: To estimate the impact of medical conditions on late life depression. rnSubjects and Methods: This was a cross-sectional study that used interviewer-administered surveys and medical record reviews. The research was conducted on a sample of 120 participants, 60 patients with late life depression and 60 community-dwelling older adults without depressive symptoms, aged 60+. All participants were examined using a general questionnaire created for the purpose of the study, the existing medical records, the Geriatric Depression Scale and Charlson Comorbidity Index (CCI- a weighted index of 19 diseases that were found to be associated with mortality and other important health outcomes). The research excluded patients with other psychiatric disorders or dementia.rnResults: The patients with late life depression were suffering from larger number of chronic diseases than non-depressed elderly people, especially heart disease (x2=5.63, df=1, p=0.018, OR=2.59), cancers (x2=4.8, df=1, p=0.028, OR=7.79), hearing impairments (x2=6.97, df=1, p=0.0083, OR=3.00), vision impairments (x2=4.37, df=2, p=0.012), and chronic pain (x2=19.38, df=1, p=<0.001, OR=6.93). rnConclusion: These data suggest that late life depression risk is elevated among elderly patients with comorbid chronic diseases and point to a necessity of routine screening and early treatment of depression in patients with chronic diseases in primary care practice.rn